Stężenie cytokin w surowicy krwi u psów z padaczką idiopatyczną i strukturalną: badanie przekrojowe

Neuroimmune mechanisms may contribute to epilepsy but circulating cytokine patterns in dogs with distinct clinical classifications of epilepsy remain incompletely characterized. This exploratory cross-sectional study compared serum concentrations of seven cytokines associated with Th1, Th2, Th17, inflammatory, and regulatory immune responses among healthy dogs and dogs clinically classified as having idiopathic epilepsy (IE) or structural epilepsy (SE). Twenty-eight dogs were included: health controls (n = 11), IE (n = 10), and SE (n = 7). Serum concentrations of IL-2, IL-4, IL-6, IL-10, IL-17, TNF-α, and IFN-γ were measured using a human Cytometric Bead Array previously applied to canine samples. Dogs clinically classified as having SE showed lower measured serum IFN-γ concentrations than healthy controls [median (IQR): [6.95 (5.68) vs. [7.66 (14.8) pg/mL; p = 0.010]. No statistically significant differences were detected for the other cytokines or between dogs with IE and healthy controls. These findings indicate that the evaluated epilepsy groups did not exhibit a generalized serum cytokine signature, but the lower measured IFN-γ concentration may represent a specific peripheral immune alteration associated with the clinical classification of structural epilepsy. Although the specific underlying etiologies of the SE cases were not established, these results provide a basis for further investigation of cytokine dynamics and immune phenotypes in canine epilepsy longitudinal designs.