Wpływ terapii muzyczną na zmniejszenie napadów epilepsji: przegląd systematyczny i meta-analiza
Effects of music interventions on seizure outcomes in people with epilepsy: a systematic review and meta‑analysis
W skrócie
Badacze przeanalizowali 15 badań naukowych, aby sprawdzić, czy słuchanie muzyki lub inne formy terapii muzycznej pomagają pacjentom z epilepsją zmniejszyć liczbę napadów. Wyniki pokazały, że muzyka może mieć pozytywny efekt, ale obecne badania nie dają ostatecznej pewności ze względu na niewielką liczbę pacjentów i różne sposoby badań. Naukowcy zapostulowali potrzebę przeprowadzenia większych, lepiej przygotowanych badań, aby dokładnie potwierdzić, czy terapia muzyczna rzeczywiście pomaga w leczeniu epilepsji.
Oryginalny abstract (angielski)
OBJECTIVES: To evaluate effects of music interventions on seizure outcomes in people with epilepsy. METHODS: We performed a systematic review and meta‑analysis of controlled and single‑arm studies. Searches were conducted in four English databases, two trial registries, and three Chinese databases, up to October 11, 2025. Dichotomous outcomes were pooled as odds ratios (ORs) and continuous outcomes as mean differences or standardized mean differences (SMD, Hedges' g) using random‑effects models. Heterogeneity was assessed with Cochran's Q and I2. Preplanned subgroup and leave‑one‑out sensitivity analyses examined control type and study influence. Risk of bias and evidence certainty were appraised. RESULTS: Fifteen studies were included. Single‑arm syntheses suggested benefit: pooled curative‑effect rate 0.715 (95 % CI 0.584-0.846) and pre-post IED reduction -0.51 (95 % CI -0.88 to -0.13). Controlled between‑group estimates were imprecise and heterogeneous. Pooled OR for seizure response was 2.71 (95 % CI 0.61-12.12, I = 81.2 %, p = 0.19). IED responder OR was 4.57 (95 % CI 0.84-24.86, I = 68.9 %). IED frequency SMD was -1.48 (95 % CI -3.06 to 0.10, I = 95.2 %). Seizure‑frequency SMD across controlled studies was -0.004 (95 % CI -1.772 to 1.763, I = 95.6 %). Results were sensitive to individual studies and limited by small samples and variable comparators. CONCLUSIONS: Music interventions show promising within‑study effects on seizure outcomes, but controlled evidence is inconclusive due to high heterogeneity and imprecision. High‑quality, adequately powered randomized trials with standardized interventions and matched active controls are needed.