Jak pracuje mózg - badanie poznawcze u pacjentów z epilepsją
Neural Basis of Cognition
W skrócie
Badanie ma na celu lepsze zrozumienie, jak pracuje mózg i jak epilepsja wpływa na pamięć, myślenie i mowę u pacjentów z oporną na leki epilepsją. Pacjenci poddawani leczeniu chirurgicznemu otrzymają specjalne elektródy mózgowe, które rejestrują aktywność mózgu podczas testów poznawczych i snu. Wyniki mogą pomóc w lepszym diagnozowaniu i leczeniu epilepsji oraz zrozumieniu, jak choroba wpływa na funkcje poznawcze.
Oryginalny opis (angielski)
The overall purpose of this study is to better understand human cognition and human epilepsy by working with patients undergoing clinical treatment for pharmacologically resistant epilepsy. The investigators will investigate human cognition by conducting controlled experiments that focus on sensory, motor, and cognitive phenomena such as sensory processing, memory, and language. The investigators will also examine the neural underpinnings of epilepsy during both sleep and wakefulness to better understand both the foundations of epilepsy and how epilepsy affects cognition. The investigators hope to use these data to have a better understanding of cognition, epilepsy, and how the two interact. This will potentially lead to better markers for seizure onsets as well as epilepsy more generally. For this research, the investigators will use μECoG arrays manufactured by commercial partners. These arrays have passed all major ISO 10993 bio-compatibility tests. Based on this characterization and use in the intraoperative setting (limited duration and supervised usage), these devices pose a minimal risk to participants. Data will be analyzed and protected using the Duke SSRI protected research data network.