Obwodowe markery zapalenia w przewidywaniu epilepsji związanej z oponiakoma u pacjentów z oponiakoma czołowym - badanie retrospektywne
Peripheral inflammatory biomarkers for individualized preoperative prediction of meningioma-related epilepsy in patients with frontal meningioma: a retrospective cohort study
W skrócie
[Preprint - wstępne wyniki] Badanie dotyczy epilepsji, która pojawia się u pacjentów z guzami mózgu zwanymi oponiakoma czołowym. Naukowcy zbadali, czy proste badania krwi - liczba białych krwinek i płytek - mogą przewidzieć, u których pacjentów dojdzie do napadów padaczkowych przed operacją. Okazało się, że pacjenci z wyższą liczbą neutrofili (typ białych krwinek) i niższą liczbą płytek mają większe ryzyko epilepsji, co może pomóc lekarzom w lepszym planowaniu leczenia.
Oryginalny abstract (angielski)
Abstract Background Meningioma-related epilepsy (MRE) is a frequent neurological complication that can complicate perioperative management and impair long-term quality of life. Current risk assessment relies mainly on clinicoradiological characteristics, whereas the contribution of readily available peripheral inflammatory biomarkers remains insufficiently defined. This study aimed to identify routine hematological predictors of preoperative MRE and to develop an interpretable model for individualized risk estimation in patients with frontal meningioma. Methods This retrospective cohort study included 222 consecutive patients with pathologically confirmed frontal meningioma who underwent surgical resection between November 2022 and November 2025. Demographic, clinical, laboratory, imaging, and pathological variables were collected. Independent predictors of preoperative MRE were identified via multivariable logistic regression and incorporated into a nomogram. Model performance was assessed via receiver operating characteristic analysis, calibration, bootstrap internal validation with 1,000 resamples, decision curve analysis, and SHapley Additive exPlanations (SHAP). Factors associated with the seizure phenotype among patients with MRE were explored separately. Results Seventy-four patients (33.3%) underwent preoperative MRE. Compared with patients without epilepsy, those with MRE had higher neutrophil counts and lower platelet counts. In the multivariable model, the neutrophil count (odds ratio [OR] 1.25, 95% confidence interval [CI] 1.10–1.42; P