Kandybidiol (CBD) podawany w okresie utajenia nie zapobiega zwiększonej podatności na napady epileptyczne po statusie epileptycznym indukowanym litowcem i pilokarpyną

In recent years, cannabidiol (CBD) has been used as an adjunct therapy to anti-seizure medications for the control of seizures in patients with drug-resistant epilepsies. In addition to its anticonvulsant effect, CBD also well-defined anti-inflammatory properties. Since neuroinflammation can trigger various pro-epileptogenic mechanisms For this reason, CBD could play an inhibitory role in this process. Epileptogenesis is the process by which epilepsy becomes a chronic disease following a brain injury and one of its main characteristics is an increased susceptibility to seizures due to reduced seizure threshold. However, the role of CBD in modulating this susceptibility remains poorly understood. We developed an experimental protocol to discretely measure seizure threshold (DMST) 7 or 14 days after lithium-pilocarpine-induced status epilepticus (SE) through the administration of small intraperitoneal (i.p.) doses of pentylenetetrazol (15 mg/kg/ every 10 minutes). Using the DMST, we observed a significant decrease in seizure threshold after SE associated with a hypersensitivity state characterized by irritability and marked weight loss. A separate cohort of rats was treated with CBD (20mg/kg) for 14 days following SE. Treatment with CBD did not improve seizure threshold, moreover, it worsened the hypersensitivity state, and delayed the recovery following SE. Our results suggest that orally administered CBD, at a human therapeutically recommended and safe dose, does not improve susceptibility to seizure development after SE.