Krótkotrwałe narażenie na składniki zanieczyszczenia powietrza w związku z hospitalizacją z powodu epilepsji: badanie z wykorzystaniem analizy ścieżek niekorzystnych wyników
Short-term exposure to PM constituents in relation to epilepsy hospitalization: A time-stratified case-crossover study with exploratory adverse outcome pathway analysis
W skrócie
Badacze sprawdzili, czy zanieczyszczenie powietrza, szczególnie drobne cząsteczki, mogą prowadzić do pogorszenia epilepsji i hospitalizacji. Odkryli, że narażenie na te zanieczyszczenia przez kilka dni zwiększa ryzyko hospitalizacji z powodu epilepsji o około 7%, zwłaszcza u dorosłych i kobiet, a wpływ jest silniejszy w chłodnych porach roku. Wyniki sugerują, że czyszczenie powietrza może być ważne dla zmniejszenia napadów epilepsji u podatnych osób.
Oryginalny abstract (angielski)
Evidence on the association between ambient air pollution, especially PM constituents, and epilepsy remains limited, and the underlying biological mechanisms remain poorly understood. We aimed to investigate the short-term effects of particulate and gaseous pollutants on epilepsy hospitalization and explore biologically plausible pathways using an adverse outcome pathway (AOP) framework. We conducted an individual-level time-stratified case-crossover study including 4,350 epilepsy hospitalizations. Daily exposures to ambient air pollutants and PM constituents were assigned at the residential level. Conditional logistic regression was used to estimate the percentage change in epilepsy hospitalization associated with an interquartile range (IQR) increase. To explore potential mechanisms, shared targets were identified using the CTD, GeneCards, and GTEx databases, followed by protein-protein interaction, hub gene, GO/KEGG enrichment. PM and its constituents were positively associated with epilepsy hospitalization at lag 6. For an IQR increase in exposure, the percentage changes in hospitalization were 7.09%-7.94% for PM and its constituents. SO showed a significant positive association at lag 6, with a 5.52% increase in hospitalization. Stratified analyses showed that these associations statistically significant among individuals aged ≥18 years, female patients, during the cool season, and in eastern China. The AOP-informed analysis provided exploratory, hypothesis-generating biological context that identified candidate pathways linking PM exposure to epilepsy-related abnormalities, including glutamate metabolism, Ca dynamics, and maladaptive synaptic plasticity; however, these findings do not establish causal mechanisms. Short-term exposure to PM was significantly associated with increased epilepsy hospitalization. These findings suggest that fine particulate pollution may be important environmental triggers for epilepsy exacerbation.