Zmiany masy ciała u dzieci i młodzieży z epilepsją i nadwagą lub otyłością leczonych zonisamidem
Weight Changes in Children and Adolescents with Epilepsy and Overweight/Obesity Treated with Zonisamide
W skrócie
Badanie wykazało, że lek przeciwpadaczkowy zwany zonisamidem powoduje zmniejszenie się masy ciała u dzieci z epilepsją i nadwagą lub otyłością. Efekt ten obserwowano przez 2 lata u wszystkich badanych dzieci, zarówno tych z otyłością, jak i z normalną masą ciała. Naukowcy sugerują, że są potrzebne dodatkowe badania, aby lepiej zrozumieć ten efekt utraty masy ciała i sprawdzić bezpieczeństwo tego leku u dzieci.
Oryginalny abstract (angielski)
OBJECTIVE: To examine changes in weight status after initiating zonisamide in children with epilepsy and elevated body mass index (BMI). STUDY DESIGN: Retrospective chart review of children aged 2 to ≤18 years with epilepsy treated with zonisamide, assessing BMI changes over 2 years. RESULTS: A total of 140 children were included; mean age (SD) at initiation was 9.60 years (3.93). BMI categories included 28 children with severe obesity, 28 with mild-moderate obesity, 28 with overweight, and 56 with healthy weight. Participants were 56.6% female, 91.4% non-Hispanic/Latino, and 88.6% White. At 2 years, BMI score decreased significantly across all BMI groups: severe obesity -0.38 ( = 13, 95% CI -0.64 to -0.13; = 0.003), mild-moderate obesity -0.39 ( = 15, 95% CI -0.62 to -0.16; = 0.001), overweight -0.60 ( = 14, 95% CI -0.84 to -0.36; < 0.001), and healthy weight -0.46 ( = 21, 95% CI -0.63 to -0.28; < 0.001). Significant BMI score reductions were also observed across age groups: 2-10 years -0.48 ( = 40, 95% CI -0.62 to -0.34), >10-13 years -0.27 ( = 15, 95% CI -0.50 to -0.04), and ≥13 years -0.63 ( = 12, 95% CI 0.89 to -0.36). CONCLUSIONS: BMI reduction persisted up to 2 years following zonisamide initiation in children with epilepsy. Further prospective studies are needed to evaluate the weight loss effect and safety of zonisamide in children with epilepsy and elevated BMI.