Jakość życia związana ze zdrowiem i czynniki ją warunkujące u dzieci z samoograniczającą się epilepsją z ogniskami w okolicy skroniowo-śródrodkowej
Health-related quality of life and associated factors in children with self-limited epilepsy with Centrotemporal Spikes
W skrócie
Badacze zbadali jakość życia u 364 dzieci z rzadką formą epilepsji leczonych lekami przeciwpadaczkowymi. Okazało się, że dzieci z dodatkowymi problemami neurologiczno-rozwojowymi (u co czwartego dziecka) mają znacznie gorszą jakość życia, podobnie jak te z więcej napadami lub problemami widocznymi w badaniu mózgu. Wyniki pokazują, że lekarze powinni zajmować się nie tylko kontrolowaniem napadów, ale też wspierać dzieci w leczeniu towarzyszących problemów, by polepszać ich codzienne funkcjonowanie.
Oryginalny abstract (angielski)
BACKGROUND: This study investigated the health-related quality of life (HRQoL) and its associated factors in children with Self-Limited Epilepsy with Centrotemporal Spikes (SeLECTS) who were receiving antiseizure medication (ASM). METHODS: In this cross-sectional study, children aged 4-14 years with SeLECTS undergoing ASM treatment were recruited from the Children's Hospital of Chongqing Medical University (CHCMU) between January 2023 and August 2025. HRQoL was assessed using the parent-reported Quality of Life in Childhood Epilepsy Questionnaire (QOLCE-16) that consists of four domains. Both ordinary least squares (OLS) and quantile regression were employed to examine the associations between influencing factors and HRQoL, with the latter assessing how these associations varied across the outcome distribution. RESULTS: Among the 364 patients analyzed, the median total score on the QOLCE-16 (range 0-100) was 84.38 (IQR: 71.88-92.19). Neurodevelopmental comorbidities, observed in 23.4% of cases, were significantly associated with lower HRQoL, both in the OLS model (β = -15.44, SE = 1.57, p < 0.001) and across all quantiles and domains in quantile regression analysis. The strongest negative effect was observed at the 10th percentile (β = -17.57, SE = 4.46, p < 0.01). Additional factors that negatively influenced QOLCE scores at various quantiles included a higher total number of seizures, the presence of electrical status epilepticus in sleep (ESES) on electroencephalogram (EEG), and lower caregiver education level. The effect of comorbidities appeared to be dose dependent. CONCLUSION: Neurodevelopmental comorbidities significantly impair HRQoL across all quantiles and multiple domains in SeLECTS. This necessitates a clinical shift from exclusive seizure control to comprehensive management of both epilepsy and comorbidities for holistic enhancement of quality of life.